Naı̈ve T-Cell Depletion Related to Infection by X4 Human Immunodeficiency Virus Type 1 in Poor Immunological Responders to Highly Active Antiretroviral Therapy†
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چکیده
Naı̈ve T-Cell Depletion Related to Infection by X4 Human Immunodeficiency Virus Type 1 in Poor Immunological Responders to Highly Active Antiretroviral Therapy† Pierre Delobel, Marie-Thérèse Nugeyre, Michelle Cazabat, Karine Sandres-Sauné, Christophe Pasquier, Lise Cuzin, Bruno Marchou, Patrice Massip, Rémi Cheynier, Françoise Barré-Sinoussi, Jacques Izopet,* and Nicole Israël Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France; Laboratoire de Virologie EA2046-IFR30, Centre Hospitalier Universitaire, Toulouse, France; Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire, Toulouse, France; and Unité des Virus Lents, Institut Pasteur, Paris, France
منابع مشابه
Naive T-cell depletion related to infection by X4 human immunodeficiency virus type 1 in poor immunological responders to highly active antiretroviral therapy.
The reasons for poor CD4+ T-cell recovery in some human immunodeficiency virus (HIV)-infected subjects despite effective highly active antiretroviral therapy (HAART) remain unclear. We recently reported that CXCR4-using (X4) HIV-1 could be gradually selected in cellular reservoirs during sustained HAART. Because of the differential expression of HIV-1 coreceptors CCR5 and CXCR4 on distinct T-ce...
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